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Background
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CAMK2B belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. This protein is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin.
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Background
References
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- Hoogenraad,C.C., Dev. Cell 12 (4), 587-602 (2007)
- Novak,G., Synapse 59 (1), 61-68 (2006)
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