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Background
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ADAM15 is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, the protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling.
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Background
References
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- McKie N., Edwards T.Biochem. Biophys. Res. Commun. 230:335-339(1997)
- Zhang X.P., Kamata T.J. Biol. Chem. 273:7345-7350(1998)
- Poghosyan Z., Robbins S.M.J. Biol. Chem. 277:4999-5007(2002)
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List Price (USA): $235.00/0.1mg
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