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Background
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OAZ1 catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. This protein play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein expression is auto-regulated by polyamine-enhanced translational frameshifting.
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Background
References
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- Grimwood J., Gordon L.A.Nature 428:529-535(2004)
- Hayashi T., Matsufuji S.Gene 203:131-139(1997)
- Tewari D.S., Qian Y.Biochim. Biophys. Acta 1209:293-295(1994)
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