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Background
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ERK2 is a member of the MAP kinase subfamily of Ser/Thr protein kinases. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets.
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Background
References
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- Grey, A., et al., Endocrinology 144(11):4886-4893 (2003).
- Sawafuji, K., et al., Am. J. Hematol. 72(1):67-69 (2003).
- Liao, Y., et al., Mol. Cell. Biol. 23(19):6836-6848 (2003).
- Garcia-Lora, A., et al., Cancer Immunol. Immunother. 52(1):59-64 (2003).
- Lin, Y.W., et al., Carcinogenesis 24(1):53-61 (2003).
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