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Background
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DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.
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Background
References
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- Guimera, J., et al., Genomics 57(3):407-418 (1999).
- Wang, J., et al., Biochem. Biophys. Res. Commun. 250(3):704-710 (1998).
- Becker, W., et al., J. Biol. Chem. 273(40):25893-25902 (1998).
- Dahmane, N., et al., Genomics 48(1):12-23 (1998).
- Chen, H., et al., Hum. Genet. 99(2):262-265 (1997).
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