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Background
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IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family with an IGFBP domain and a thyroglobulin type-I domain. This protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.
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Background
References
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- Muzumdar,R.H., Diabetes 55 (10), 2788-2796 (2006)
- Novosyadlyy,R., Growth Horm. IGF Res. 15 (5), 313-323 (2005)
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