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Background
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Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. ILK is a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction.
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Background
References
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- Li, Y., et al., J. Clin. Invest. 112(4):503-516 (2003).
- Troussard, A.A., et al., J. Biol. Chem. 278(25):22374-22378 (2003).
- Marotta, A., et al., Br. J. Cancer 88(11):1755-1762 (2003).
- Cordes, N., et al., Br. J. Cancer 88(9):1470-1479 (2003).
- Fukuda, T., et al., J. Cell Biol. 160(7):1001-1008 (2003).
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