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Background
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PDGFRB is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses the gene to that of the translocation, ETS, leukemia gene, results in chronic myelomonocytic leukemia.
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Background
References
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- Wu, H., et al., J. Biol. Chem. 278(42):40425-40428 (2003).
- Whiteman, E.L., et al., Endocrinology 144(9):3811-3820 (2003).
- Uren, A., et al., Oncogene 22(15):2334-2342 (2003).
- Steer, E.J., et al., Acta Haematol. 107(2):113-122 (2002).
- Kawagishi, J., et al., Genomics 30(2):224-232 (1995).
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