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Background
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MATK has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
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Background
References
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- Kim, S., et al., J. Biol. Chem. 277(39):36465-36470 (2002).
- Zagozdzon, R., et al., Int. J. Oncol. 21(6):1347-1352 (2002).
- Zrihan-Licht, S., et al., J. Biol. Chem. 272(3):1856-1863 (1997).
- Jhun, B.H., et al., J. Biol. Chem. 270(16):9661-9666 (1995).
- Avraham, S., et al., J. Biol. Chem. 270(4):1833-1842 (1995).
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List Price (USA): $235.00/0.1mg
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