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Background
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FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
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Background
References
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- Gerard,M., J. Neurochem. 106 (1), 121-133 (2008)
- Shor,B., Cancer Res. 68 (8), 2934-2943 (2008)
- Jayaraman,T.,J. Biol. Chem. 267 (14), 9474-9477 (1992)
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List Price (USA): $235.00/0.1mg
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