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Background
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CYP3A4, is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens.
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Background
References
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- Sandanaraj,E., Clin. Cancer Res. 14 (21), 7116-7126 (2008)
- Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)
- Inoue,K., Jpn. J. Hum. Genet. 37 (2), 133-138 (1992)
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List Price (USA): $235.00/0.1mg
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