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Background
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Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.
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Background
References
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- Guo,M., Proc. Natl. Acad. Sci. U.S.A. 105 (7), 2331-2336 (2008)
- Kovaleski,B.J., J. Biol. Chem. 282 (44), 32274-32279 (2007)
- Kaminska,M., FEBS Lett. 581 (16), 3105-3110 (2007)
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