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Background
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BCL2L1 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis.
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Background
References
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- Boise L.H., Gonzalez-Garcia M.Cell 74:597-608(1993)
- Lo S.-C., Hannink M.J. Biol. Chem. 281:37893-37903(2006)
- Petros A.M., Nettesheim D.G.Protein Sci. 9:2528-2534(2000)
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Order Information
List Price (USA): $235.00/0.1mg
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