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Background
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EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 [PubMed 10504407]).[supplied by OMIM]
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Background
References
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- Blume-Jensen P, et al. Nature 2001. 411: 355.
- Cantrell D, J. Cell Sci. 2001. 114: 1439.
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- Robinson D, et al. Oncogene 2000. 19: 5548.
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- Vanhaesebroeck, B, et al. Biochem. J. 2000. 346: 561.
- Van Weering D, et al. Recent Results Cancer Res. 1998. 154: 271.
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