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Background
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Upon serum stimulation, KIS, a member of the Ser/Thr protein kinase family, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. This protein, which contains 1 RRM (RNA recognition motif)domain, may be involved in trafficking and/or processing of RNA. KIS is widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
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Background
References
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- Bieche, I., et al., Brain Res. Mol. Brain Res. 114(1):55-64 (2003).
- Boehm, M., et al., EMBO J. 21(13):3390-3401 (2002).
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