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Background
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FGF4 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The gene for FGF4 was identified by its oncogenic transforming activity. The gene for FGF4 and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.
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Background
References
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- Yamamoto, H., et al., Oncogene 21(6):899-908 (2002).
- Koh, K.R., et al., Leuk. Res. 26(10):933-938 (2002).
- Sieuwerts, A.M., et al., Thromb. Haemost. 87(4):674-683 (2002).
- Lopez-Sanchez, C., et al., Cell Tissue Res. 309(2):237-249 (2002).
- Galland, F., et al., Cytogenet. Cell Genet. 60(2):114-116 (1992).
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