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Background
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MEG1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.
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Background
References
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- Hironaka, K., et al., J. Biol. Chem. 275(21):16167-16173 (2000).
- Gu, M., et al., Proc. Natl. Acad. Sci. U.S.A. 93(23):12980-12985 (1996).
- Gu, M., et al., J. Biol. Chem. 271(44):27751-27759 (1996).
- Gu, M.X., et al., Proc. Natl. Acad. Sci. U.S.A. 88(13):5867-5871 (1991).
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