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Background
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Rad9 is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade.
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Background
References
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- Maniwa, Y., et al., Cancer 103(1):126-132 (2005).
- Wang, W., et al., Proc. Natl. Acad. Sci. U.S.A. 101(48):16762-16767 (2004).
- Lindsey-Boltz, L.A., et al., (er) Nucleic Acids Res. 32(15):4524-4530 (2004).
- Toueille, M., et al., (er) Nucleic Acids Res. 32(11):3316-3324 (2004).
- Loegering, D., et al., J. Biol. Chem. 279(18):18641-18647 (2004).
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