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Catalog #
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Source:
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Lot #
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Size:
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AP1023b
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Rabbit
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SH070917T
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_715640, Q8IZV0
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RB12504
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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77817 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DNMT3A2.
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Other Names:
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DNA cytosine methyltransferase 3A2; DNMT3A2
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Application Data:
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Western blot analysis of DNMT3A2 Antibody (C-term) (Cat.# AP1023b) in HepG2 cell line lysates (35ug/lane). DNMT3A2 (arrow) was detected using the purified Pab. |
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Background:
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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. DNMT3A is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
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Background References:
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:100~500 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long
term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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