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Catalog #
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Source:
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Lot #
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Size:
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AP1046a
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Rabbit
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SH070226C
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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O75164, NP_055478
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RB10787
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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120720 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human JMJD2A.
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Other Names:
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JMJD2A; JHDM3A, JMJD2, KIAA0677
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Application Data:
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Western blot analysis of JMJD2A(arrow) using rabbit polyclonal JMJD2A (N-term)(Cat. #AP1046a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the JMJD2A gene (Lane 2) (Origene Technologies). |
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Background:
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JMJD2A is a member of the Jumonji domain 2 (JMJD2) family and a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
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Background References:
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- Gray S.G., Iglesias A.H.J. Biol. Chem. 280:28507-28518(2005)
- Zhang D., Yoon H.-G.Mol. Cell. Biol. 25:6404-6414(2005)
- Whetstine J.R., Nottke A.Cell 125:467-481(2006)
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:50~100 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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