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Catalog #
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Source:
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Lot #
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Size:
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AP1251a
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Rabbit
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SH031201J
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_113637, Q8NF64
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RB4506
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, IHC, E
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H
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96537 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PIASz.
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Other Names:
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Zinc finger MIZ domain-containing protein 2; PIAS-like protein Zimp7; ZMIZ2; KIAA1886; ZIMP7
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Application Data:
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
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Background:
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PIASz is a members of the PIAS (protein inhibitor of activated signal transducer and activator of transcription) family of proteins, negative regulators of the Janus family of tyrosine kinase (JAK)-signal transducer and activator of transcription pathway. PIAS proteins have been shown to act as transcriptional co-regulators of multiple signaling pathways in various cellular processes. PIASz increases ligand-dependent transcriptional activity of androgen receptor and other nuclear hormone receptors, possibly through alteration of chromatin structure by SWI/SNF-like BAF complexes.
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Background References:
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:100~500 |
| Immunohistochemistry | 1:50~100 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long
term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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