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Catalog #
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Source:
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Lot #
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Size:
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AP1316a
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Rabbit
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SH020704U
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_066950, Q13794
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RB0608
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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E
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H
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6030 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region (BH3 domain) of human Noxa.
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Other Names:
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PMAIP1, phorbol-12-myristate-13-acetate-induced protein 1; PMA-induced protein 1; Immediate-early-response protein APR; PMAIP1
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Application Data:
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This product is offered at a low price as part of the Abgent Product Investigation Program. Additionally, submit your positive data for this or any Abgent antibody to our Data Rewards Program and receive a free gift.
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Background:
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The expression of the Noxa gene, a BH3 only member of the Bcl2 family, involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53 deficient thymocytes. Co-immunoprecipitation data suggests that Noxa protein may interact with proteins belonging to the Bcl2 family, such as, BclXL and Mcl1. Blocking endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation induced apoptosis, suggesting that Noxa may mediate p53 dependent apoptosis.
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Background References:
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- Jansson, A.K., et al., Oncogene 22(30):4675-4678 (2003).
- Hijikata, M., et al., J. Virol. 64(10):4632-4639 (1990).
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Product Citations:
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Application Notes:
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| The suggested dilution will be: | |
| ELISA | 1:1,000 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long
term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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