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Catalog #
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Source:
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Lot #
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Size:
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AP1418b
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Rabbit
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SA080218AF
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_001835, P02458
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RB13830
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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141785 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human COL2A1.
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Other Names:
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Collagen alpha-1(II) chain; Alpha-1 type II collagen; Chondrocalcin
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Application Data:
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Western blot analysis of anti-COL2A1 Antibody (C-term) (RB13830) in 293 cell line lysates (35ug/lane). COL2A1(arrow) was detected using the purified Pab (1:60 dilution). |
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Background:
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Alpha-1 chain of type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutant forms of this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
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Background References:
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- Olavarrieta,L., Clin. Genet. 73 (3), 262-267 (2008)
- McAlinden,A., Hum. Mutat. 29 (1), 83-90 (2008)
- Forzano,F., Am. J. Med. Genet. A 143 (23), 2815-2820 (2007)
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:50~100 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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