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Catalog #
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Source:
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Lot #
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Size:
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AP1490c
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Rabbit
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SH080128L
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_004818, Q9UNQ0
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RB13782
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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72314 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human ABCG2.
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Other Names:
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ATP-binding cassette sub-family G member 2; Placenta-specific ATP-binding cassette transporter; Breast cancer resistance protein; Mitoxantrone resistance-associated protein; CD338 antigen; CDw338; ABCP, BCRP, BCRP1, MXR
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Application Data:
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Western blot analysis of ABCG2 Antibody (Center) in 293 cell line lysates (35ug/lane). ABCG2(arrow) was detected using the purified Pab (1:60 dilution). |
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Background:
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ABCG2 is a membrane-associated protein included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.
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Background References:
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- Xie,Y., J. Biol. Chem. 283 (6), 3349-3356 (2008)
- Tamura,A., Drug Metab. Pharmacokinet. 22 (6), 428-440 (2007)
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:50~100 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long
term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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