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Catalog #
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Source:
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Lot #
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Size:
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AP1721a
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Rabbit
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SH030122S
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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PDGB_HUMAN
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RB2203
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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27283 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PDGFB.
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Other Names:
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Application Data:
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The anti-PDGFC C-term Pab (Cat. #AP1721a) is used in Western blot to detect PDGFC in A375 cell lysate. |
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Background:
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PDGFB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor alpha polypeptide, where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor.
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Background References:
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- Muller, C., et al., J. Biol. Chem. 278(20):18330-18335 (2003).
- Laprise, M.H., et al., Blood 100(10):3578-3587 (2002).
- Maire, G., et al., Cancer Genet. Cytogenet. 134(2):156-161 (2002).
- Andrae, J., et al., Biochem. Biophys. Res. Commun. 296(3):604-611 (2002).
- Ehrlich, H.P., et al., Cytokines Cell Mol Ther 7(3):85-90 (2002).
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:100~500 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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