|
Catalog #
|
Source:
|
Lot #
|
Size:
|
|
AP1904a
|
Rabbit
|
SH050721F
|
0.1 mg
|
|
Concentration:
|
Accession:
|
Clone Name:
|
Isotype:
|
|
0.25 mg/ml
|
NP_075447, Q9BZ95
|
RB8016
|
Rabbit Ig
|
|
Applications:
|
Reactivity:
|
MW (kDa):
|
|
E
|
H
|
161613 Da
|
|
Target/Specificity:
|
|
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human WHSC1L1.
|
|
Other Names:
|
|
Histone-lysine N-methyltransferase NSD3; Nuclear SET domain-containing protein 3; WHSC1-like protein 1; Wolf-Hirschhorn syndrome candidate 1-like protein 1; Whistle; NSD3; DC28
|
|
Application Data:
|
This product is offered at a low price as part of the Abgent Product Investigation Program. Additionally, submit your positive data for this or any Abgent antibody to our Data Rewards Program and receive a free gift.
|
|
|
Background:
|
|
WHSC1L1 is a histone methyltransferase. This protein preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia.
|
|
Background References:
|
- Angrand, P.O., et al., Genomics 74(1):79-88 (2001).
- Stec, I., et al., FEBS Lett. 473(1):1-5 (2000).
- Stec, I., et al., Genomics 76 (1-3), 5-8 (2001) (): ().
|
|
Product Citations:
|
|
|
|
Application Notes:
|
| The suggested dilution is: | |
| ELISA | 1:1,000 |
|
|
Format:
|
|
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
|
|
Storage:
|
|
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
|
|
Precautions:
|
|
This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
|
