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Catalog #
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Source:
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Lot #
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Size:
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AP2042c
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Rabbit
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SH070807I
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_005420, P49767
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RB11715
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, IHC, E
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H
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46883 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human VEGF3.
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Other Names:
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Vascular endothelial growth factor C [Precursor]; VEGF-C; Vascular endothelial growth factor-related protein; VRP; Flt4 ligand; Flt4-L; VEGFC;
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Application Data:
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Western blot analysis of VEGF3 Antibody (Center) polyclonal antibody(Cat.#AP2042c)(arrow). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the VEGF3 gene (Lane 2) (Origene Technologies). |
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with VEGF3 Antibody (Center M263)(Cat.#AP2042c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
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Background:
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VEGF3 is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
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Background References:
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- Byeon, J.S., et al., J. Gastroenterol. Hepatol. 19(6):648-654 (2004).
- Su, J.L., et al., Cancer Res. 64(2):554-564 (2004).
- Yan, C., et al., World J. Gastroenterol. 10(6):783-790 (2004).
- Hsieh, C.Y., et al., J. Biomed. Sci. 11(2):249-259 (2004).
- Liu, X.E., et al., World J. Gastroenterol. 10(3):352-355 (2004).
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:50~100 |
| Immunohistochemistry | 1:10~50 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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