|
Catalog #
|
Source:
|
Lot #
|
Size:
|
|
AP2401a
|
Rabbit
|
SH040114B; SH040114C
|
0.1 mg
|
|
Concentration:
|
Accession:
|
Clone Name:
|
Isotype:
|
|
0.25 mg/ml
|
NP_001127, Q15109
|
RB4825/4826
|
Rabbit Ig
|
|
Applications:
|
Reactivity:
|
MW (kDa):
|
|
IHC, E
|
H
|
42802 Da
|
|
Target/Specificity:
|
|
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human AGER.
|
|
Other Names:
|
|
Advanced glycosylation end product-specific receptor [Precursor]; Receptor for advanced glycosylation end products; AGER; RAGE
|
|
Application Data:
|
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
|
|
Background:
|
|
AGER is a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products.
|
|
Background References:
|
- Schlueter, C., et al., Biochim. Biophys. Acta 1630(1):1-6 (2003).
- Shanmugam, N., et al., J. Biol. Chem. 278(37):34834-34844 (2003).
- Kuniyasu, H., et al., Oncol. Rep. 10(2):445-448 (2003).
- Hsieh, H.L., et al., Biochem. Biophys. Res. Commun. 307(2):375-381 (2003).
- Rocken, C., et al., Am. J. Pathol. 162(4):1213-1220 (2003).
|
|
Product Citations:
|
|
|
|
Application Notes:
|
| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Immunohistochemistry | 1:50~100 |
|
|
Format:
|
|
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
|
|
Storage:
|
|
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
|
|
Precautions:
|
|
This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
|
