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Catalog #
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Source:
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Lot #
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Size:
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AP2541b
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Rabbit
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SH030212I
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_000480, P46100
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RB2362
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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E
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H
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282566 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ATRX.
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Other Names:
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Transcriptional regulator ATRX; ATP-dependent helicase ATRX; X-linked helicase II; X-linked nuclear protein; XNP; Znf-HX; ATRX; RAD54L; XH2;
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Application Data:
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This product is offered at a low price as part of the Abgent Product Investigation Program. Additionally, submit your positive data for this or any Abgent antibody to our Data Rewards Program and receive a free gift.
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Background:
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ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. Theses mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis.
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Background References:
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- Mazina, O.M., et al., J. Biol. Chem. 279(50):52042-52051 (2004).
- Tang, P., et al., Trends Endocrinol. Metab. 15(7):339-344 (2004).
- Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004).
- Steensma, D.P., et al., Blood 103(6):2019-2026 (2004).
- Tang, J., et al., J. Biol. Chem. 279(19):20369-20377 (2004).
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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