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Catalog #
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Source:
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Lot #
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Size:
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AP2792a
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Rabbit
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SH080605K
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_002346, P20645
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RB15076
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, IHC, E
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H, M
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30993 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human M6PR.
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Other Names:
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Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-MPR; 46 kDa mannose 6-phosphate receptor; MPR 46; M6PR; MPR46; MPRD
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Application Data:
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Western blot analysis of M6PR Antibody (N-term)(Cat. #AP2792a) in mouse brain tissue lysates (35ug/lane). M6PR (arrow) was detected using the purified Pab. |
Formalin-fixed and paraffin-embedded human testis tissue reacted with M6PR antibody (N-term) (Cat.#AP2792a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
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Background:
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M6PR is a receptor for mannose-6-phosphate groups on lysosomal enzymes. The receptor forms a homodimer or homotetramer for intracellular targeting of lysosomal enzymes and export of newly synthesized lysosomal enzymes into the cell secretions. The receptor is an integral membrane protein which localizes to the trans-Golgi reticulum, endosomes, and the plasma membrane.
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Background References:
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- Perez-Victoria,F.J., Mol. Biol. Cell 19 (6), 2350-2362 (2008)
- Mari,M., Traffic 9 (3), 380-393 (2008)
- Lemansky,P., J. Leukoc. Biol. 81 (4), 1149-1158 (2007)
- Chen,J.J., Cell 119 (7), 915-926 (2004)
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blot | 1:50~100 |
| Immunohistochemistry | 1:10~50 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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