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Catalog #
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Source:
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Lot #
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Size:
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AP2848b
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Rabbit
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SH090715BI
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_006182, Q9UQ80
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RB19220
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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43787 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human EBP1.
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Other Names:
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Proliferation-associated protein 2G4; Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1; PA2G4; EBP1
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Application Data:
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Western blot analysis of EBP1 antibody (C-term) (Cat.# AP2848b) in MCF-7 cell line lysates (35ug/lane). EBP1 (arrow) was detected using the purified Pab. |
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Background:
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PA2G4 is an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells.
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Background References:
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- Zhang,Y., Mol. Cancer Ther. 7 (10), 3176-3186 (2008)
- Zhang,Y., Cancer Lett. 265 (2), 298-306 (2008)
- Okada,M., J. Biol. Chem. 282 (50), 36744-36754 (2007)
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:50~100 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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