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Catalog #
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Source:
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Lot #
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Size:
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AP6138a
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Rabbit
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SH021219G
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_001392
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RB1825
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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41109 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human EDG2.
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Other Names:
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Application Data:
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The anti-EDG2 N-term Antibody (Cat.#AP6138a) is used in Western blot to detect EDG2 in A375 lysate. |
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Background:
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The EDG2 integral membrane protein is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion.
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Background References:
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- Matsuda, A., et al., Oncogene 22(21):3307-3318 (2003).
- Van Leeuwen, F.N., et al., J. Biol. Chem. 278(1):400-406 (2003).
- Shida, D., et al., Cancer Res. 63(7):1706-1711 (2003).
- Cervera, P., et al., Glia 38(2):126-136 (2002).
- An, S., et al., Mol. Pharmacol. 54(5):881-888 (1998).
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Product Citations:
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- Boucharaba, Ahmed, et al. PNAS 2006 Jun 20;103(25):9643-9648. (Applications: WB)
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:100~500 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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