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Catalog #
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Source:
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Lot #
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Size:
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AP6312b
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Rabbit
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SH030127V
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_064557, Q8TCT7
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RB2274
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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E
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H
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61898 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human SPPL2b.
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Other Names:
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Signal peptide peptidase-like 2B; SPP-like 2B protein; SPPL2b protein; Intramembrane protease 4; IMP4; Presenilin-like protein 1; SPPL2B; KIAA1532; PSL1;
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Application Data:
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This product is offered at a low price as part of the Abgent Product Investigation Program. Additionally, submit your positive data for this or any Abgent antibody to our Data Rewards Program and receive a free gift.
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Background:
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Signal peptide peptidase (SPP) is an aspartyl protease that mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, SPP contains a critical GXGD motif in its C-terminal catalytic center. Several presenilin homologues/SPP-like proteins (PSHs/SPPL) have been identified. Unlike the ER localization of SPP and other SPPL proteins, SPPL2b is targeted through the secretory pathway to endosomes/lysosomes.
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Background References:
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- Friedmann, E., et al., J. Biol. Chem. 279(49):50790-50798 (2004).
- Grigorenko, A.P., et al., Biochemistry Mosc. 67(7):826-835 (2002).
- Weihofen, A., et al., Science 296(5576):2215-2218 (2002).
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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