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Catalog #
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Source:
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Lot #
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Size:
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AP6321b
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Rabbit
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SA081031AG
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/mL
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NP_005542
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RB6101
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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28671 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human KLK2.
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Other Names:
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Kallikrein 2, Tissue kallikrein 2, Glandular kallikrein-1, hGK-1
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Application Data:
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Western blot analysis of Kallikrein 2 (KLK2) Antibody (C-term) (Cat.# AP6321b) in K562 cell line lysates (35ug/lane). KLK2 (arrow) was detected using the purified Pab. |
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Background:
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Kallikreins are a group of serine proteases manifesting diverse physiological functions. The glandular kallikreins are a distinct group of serine proteases with an ability to release vasoactive peptides from kininogen in vitro, although the kininogenase activity of different kallikreins is highly variable. Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Many kallikrein genes are differentially expressed in various malignancies. Human glandular kallikrein (hK2; encoded by the KLK2 gene) is an emerging tumor marker for prostate cancer.
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Background References:
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- Haese, A., et al., J Urol. 2005 Mar;173(3):752-6.
- Chiang, C.H., et al., J Urol. 2005 Feb;173(2):429-32.
- Clements, J.A., et al., Crit Rev Clin Lab Sci. 2004;41(3):265-312.
- Borgono, C.A., et al., Mol Cancer Res. 2004 May;2(5):257-80.
- Yousef, G.M., Clin Biochem. 2003 Sep;36(6):443-52.
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western Blot | 1:50~100 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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