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Catalog #
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Source:
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Lot #
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Size:
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AP6402a
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Rabbit
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SH050416H
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_004553.1
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RB7371
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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51651 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide in the C-terminal region of human Park2.
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Other Names:
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Parkin isoform 1; Parkin; E3 ubiquitin ligase; Ubiquitin E3 ligase PRKN; Parkinson juvenile disease protein 2; Parkinson disease protein 2; PRKN
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Application Data:
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Western blot analysis of anti-PARK2 (Parkin) Antibody (N-term) (Cat.#AP6402a) in NCI-H460 cell line lysates (35ug/lane). PARK2 (Parkin)(arrow) was detected using the purified Pab. |
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Background:
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Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function.
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Background References:
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- Kumru, H., et al., Ann. Neurol. 56(4):599-603 (2004).
- Pigullo, S., et al., Parkinsonism Relat. Disord. 10(6):357-362 (2004).
- Yao, D., et al., Proc. Natl. Acad. Sci. U.S.A. 101(29):10810-10814 (2004).
- West, A.B., et al., J. Biol. Chem. 279(28):28896-28902 (2004).
- Wang, F., et al., Genes Chromosomes Cancer 40(2):85-96 (2004).
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:100~500 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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