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Pael-R (GPR37) Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)

Catalog # Source: Lot # Size:
AP6410b Rabbit SH050420J 0.1 mg
Concentration: Accession: Clone Name: Isotype:
0.25 mg/ml NP_005293.1 RB7397 Rabbit Ig
Applications: Reactivity: MW (kDa):
WB, IHC, E H 67114 Da
Target/Specificity:
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide in the C-terminal region of human Pael-R (GPR37).
Other Names:
Endothelin B receptor-like protein-1; ETBR-LP-1; Parkin-associated endothelin receptor-like receptor; endothelin receptor type B-like; PAELR; G protein-coupled receptor 37; GPR37
Application Data:
Pael-R (GPR37) Antibody (C-term)

(LEFT)Western blot analysis of anti-Pael-R (GPR37) Pab (Cat. #AP6410b) in mouse brain tissue lysate. Pael-R (GPR37) (arrow) was detected using the purified Pab. (RIGHT)Western blot analysis of anti-Pael-R (GPR37) Antibody (C-term)(Cat. #AP6410b) in K562 cell line lysates (35ug/lane). Pael-R (arrow) was detected using the purified Pab.

 Pael-R (GPR37) Antibody (C-term)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Background:
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.
Background References:
  1. Yang,Y., et al. Neuron 37 (6), 911-924 (2003)
  2. Imai,Y., et al. Mol. Cell 10 (1), 55-67 (2002)
  3. Imai,Y., et al. Cell 105 (7), 891-902 (2001)
  4. Marazziti,D., et al. Genomics 45 (1), 68-77 (1997)
  5. Zeng,Z., et al. BBRC 233 (2), 559-567 (1997)
Product Citations:
Application Notes:
The suggested dilution is:
ELISA1:1,000
Western blotting1:100~500
Immunohistochemistry1:50~100
Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage:
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Precautions:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.