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Catalog #
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Source:
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Lot #
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Size:
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AP6709a
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Rabbit
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SH090914AM
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_003245
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RB15494
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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23171 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human TIMP1.
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Other Names:
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Metalloproteinase inhibitor 1; Tissue inhibitor of metalloproteinases; TIMP-1; Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; TIMP; CLGI; TIMP1
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Application Data:
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Western blot analysis of TIMP1 Antibody (N-term) (Cat. #AP6709a) in CEM cell line lysates (35ug/lane). TIMP1 (arrow) was detected using the purified Pab. |
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Background:
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TIMP1 belongs to the TIMP family. The proteins in this family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.
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Background References:
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- Safranek,J., Anticancer Res. 29 (7), 2513-2517 (2009)
- Onal,I.K., Eur. J. Intern. Med. 20 (4), 369-372 (2009)
- Okamura,H., Int. J. Oncol. 35 (1), 181-186 (2009)
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:50~100 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at 20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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