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Catalog #
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Source:
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Lot #
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Size:
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AP7102a
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Rabbit
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SH051012H
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_660302, Q8NER5
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RB8195
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, IHC, E
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H
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54871 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR1C.
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Other Names:
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Activin receptor type 1C [Precursor]; ACTR-IC; Activin receptor-like kinase 7; ALK-7; ACVR1C; ALK7;
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Application Data:
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Western blot analysis of anti-ACVR1C Antibody (N-term A48) (Cat.#AP7102a) in HepG2 and Hela cell line lysate (35ug/lane). ACVR1C (arrow) was detected using the purified Pab. |
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
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Background:
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ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.
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Background References:
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- Munir, S., et al., J. Biol. Chem. 279(30):31277-31286 (2004).
- Kim, B.C., et al., J. Biol. Chem. 279(27):28458-28465 (2004).
- Roberts, H.J., et al., Biol. Reprod. 68(5):1719-1726 (2003).
- Tsuchida, K., et al., Mol. Cell. Endocrinol. 220 (1-2), 59-65 (2004) (): ().
- Bondestam, J., et al., Cytogenet. Cell Genet. 95 (3-4), 157-162 (2001) (): ().
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:100~500 |
| Immunohistochemistry | 1:50~100 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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