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Catalog #
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Source:
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Lot #
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Size:
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AP7125a
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Rabbit
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SH060117H
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_001339, O43293
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RB8513
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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E
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H
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52536 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human DAPK3.
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Other Names:
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Death-associated protein kinase 3; DAP kinase 3; DAP-like kinase; Dlk; ZIP-kinase; DAPK3; ZIPK;
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Application Data:
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This product is offered at a low price as part of the Abgent Product Investigation Program. Additionally, submit your positive data for this or any Abgent antibody to our Data Rewards Program and receive a free gift.
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Background:
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Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. DAPK3 forms a homodimer or heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. DAPK3 also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. This protein interacts with AATF and CDC5L.
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Background References:
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- Endo, A., et al., J. Biol. Chem. 279(40):42055-42061 (2004).
- Kawai, T., et al., Mol. Cell. Biol. 23(17):6174-6186 (2003).
- Preuss, U., et al., Nucleic Acids Res. 31(3):878-885 (2003).
- Page, G., et al., Oncogene 18(51):7265-7273 (1999).
- Murata-Hori, M., et al., FEBS Lett. 451(1):81-84 (1999).
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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