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Catalog #
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Source:
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Lot #
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Size:
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AP7425c
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Rabbit
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SH090327J
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_003806, Q13444
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RB17771
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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87717 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human ADAM15.
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Other Names:
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Metargidin; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; MDC-15; A disintegrin and metalloproteinase domain 15; ADAM 15; ADAM15; MDC15
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Application Data:
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Western blot analysis of anti-ADAM15 Antibody (Center) (Cat.#AP7425c) in NCI-H460 cell line lysates (35ug/lane). ADAM15 (arrow) was detected using the purified Pab. |
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Background:
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ADAM15 is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, the protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling.
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Background References:
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- McKie N., Edwards T.Biochem. Biophys. Res. Commun. 230:335-339(1997)
- Zhang X.P., Kamata T.J. Biol. Chem. 273:7345-7350(1998)
- Poghosyan Z., Robbins S.M.J. Biol. Chem. 277:4999-5007(2002)
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:50~100 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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