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Catalog #
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Source:
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Lot #
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Size:
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AP7714c
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Rabbit
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SH080129A
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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P42679
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RB13937
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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IHC, E
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H
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56469 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human MATK.
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Other Names:
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Megakaryocyte-associated tyrosine-protein kinase, Tyrosine-protein kinase CTK, Protein kinase HYL, Hematopoietic consensus tyrosine-lacking kinase
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Application Data:
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Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with MATK antibody (Center) (Cat.#AP7714c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
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Background:
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MATK has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
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Background References:
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- Kim, S., et al., J. Biol. Chem. 277(39):36465-36470 (2002).
- Zagozdzon, R., et al., Int. J. Oncol. 21(6):1347-1352 (2002).
- Zrihan-Licht, S., et al., J. Biol. Chem. 272(3):1856-1863 (1997).
- Jhun, B.H., et al., J. Biol. Chem. 270(16):9661-9666 (1995).
- Avraham, S., et al., J. Biol. Chem. 270(4):1833-1842 (1995).
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Immunohistochemistry | 1:10~50 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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