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Catalog #
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Source:
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Lot #
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Size:
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AP7776b
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Rabbit
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SH080320E
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_001648
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RB14425
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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IHC, E
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H
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27895 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human AREG.
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Other Names:
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Amphiregulin; Amphiregulin (Schwannoma-derived growth factor) ; AREG; AR; SDGF; CRDGF; MGC13647
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Application Data:
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Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with the AREG antibody (C-term) (Cat.#AP7776b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
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Background:
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AREG is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This protein is associated with a psoriasis-like skin phenotype.
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Background References:
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- Shim,J.Y., J. Korean Med. Sci. 23 (5), 857-863 (2008)
- Eckstein,N., J. Biol. Chem. 283 (2), 739-750 (2008)
- Revillion,F., Ann. Oncol. 19 (1), 73-80 (2008)
- Kimura,H., Nature 348 (6298), 257-260 (1990)
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Immunohistochemistry | 1:10~50 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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