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Catalog #
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Source:
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Lot #
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Size:
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AP7793b
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Rabbit
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SH081103G
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_000780, P12821
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RB16489
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H, M
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149715 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ACE.
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Other Names:
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Angiotensin-converting enzyme; Dipeptidyl carboxypeptidase I; Kininase II; CD143; Angiotensin-converting enzyme, soluble form; ACE; DCP; DCP1
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Application Data:
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Western blot analysis of anti-ACE Antibody (C-term) (Cat.#AP7793b) in mouse lung tissue lysates (35ug/lane). ACE (arrow) was detected using the purified Pab. |
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Background:
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ACE is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active.
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Background References:
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- du Cheyron,D.,Crit. Care Med. 36 (12), 3178-3183 (2008)
- Pang,S., Biochem. J. 358 (PT 1), 185-192 (2001)
- Woodman,Z.L., Biochem. J. 347 PT 3, 711-718 (2000)
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:50~100 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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