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Catalog #
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Source:
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Lot #
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Size:
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AP7958c
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Rabbit
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SH090421E
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_612815, Q07817
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RB16884
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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26049 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human BCL2L1.
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Other Names:
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Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X ; synonyms: BCLX; synonyms: BCL2L; name: BCL2L1
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Application Data:
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(LEFT)Western blot analysis of BCL2L1 antibody (Center) (Cat.#AP7958c) in Y79 cell line lysates (35ug/lane). BCL2L1(arrow) was detected using the purified Pab.
(RIGHT)Western blot analysis of BCL2L1 Antibody (Center) (Cat.#AP7958c) in mouse brain tissue lysates (35ug/lane).BCL2L1(arrow) was detected using the purified Pab. |
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Background:
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BCL2L1 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis.
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Background References:
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- Boise L.H., Gonzalez-Garcia M.Cell 74:597-608(1993)
- Lo S.-C., Hannink M.J. Biol. Chem. 281:37893-37903(2006)
- Petros A.M., Nettesheim D.G.Protein Sci. 9:2528-2534(2000)
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:50~100 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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