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Catalog #
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Source:
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Lot #
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Size:
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AP8414a
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Rabbit
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SH020627N
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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P23470
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RB0553
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H, M
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162058 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human PTPgamma.
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Other Names:
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Application Data:
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The anti-PTPgamma Center Pab (Cat. #AP8414a) is used in Western blot to detect PTPgamma in mouse brain tissue lysate. |
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Background:
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PTPgamma is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. The gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.
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Background References:
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- Liu, S., et al., Breast Cancer Res. Treat. 71(1):21-35 (2002).
- Kastury, K., et al., Genomics 32(2):225-235 (1996).
- Barnea, G., et al., Mol. Cell. Biol. 13(3):1497-1506 (1993).
- LaForgia, S., et al., Proc. Natl. Acad. Sci. U.S.A. 88(11):5036-5040 (1991).
- Krueger, N.X., et al., EMBO J. 9(10):3241-3252 (1990).
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:100~500 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long
term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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