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Catalog #
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Source:
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Lot #
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Size:
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AT1246a
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mouse
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7012
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0.1mg
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Type:
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Accession:
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Clone Name:
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Isotype:
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Mab
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NP_000480
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3C9
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IgG1 Kappa
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Applications:
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Reactivity:
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MW:
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ELISA,S-ELISA,WB-Re
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H
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282566 Da
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Target/Specificity:
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ATRX (NP_000480, 2311 a.a. ~ 2411 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Other Names:
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ATR2, MGC2094, MRXS3, RAD54, RAD54L, SHS, XH2, XNP, ZNFHXalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
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Application Data:
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Detection limit for recombinant GST tagged ATRX is approximately 0.1ng/ml as a capture antibody. |
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Background:
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The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
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Background References:
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Product Citations:
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Application Notes:
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| ELISA | 1ug/ml~3ng/ml |
| Western blot | 1:500~1000 |
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Format:
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Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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Storage:
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For continuous use, store at 2-8°C for one-two days. For extended storage, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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