|
Catalog #
|
Source:
|
Lot #
|
Size:
|
|
AT1281a
|
mouse
|
|
0.1mg
|
|
Type:
|
Accession:
|
Clone Name:
|
Isotype:
|
|
Mab
|
NP_060484
|
3D9
|
IgG2a Kappa
|
|
Applications:
|
Reactivity:
|
MW:
|
|
ELISA,WB-Re,WB-Tr
|
H
|
91197 Da
|
|
Target/Specificity:
|
|
BCL11A (NP_060484, 1 a.a. ~ 89 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
|
|
Other Names:
|
|
BCL11A-L, BCL11A-S, BCL11A-XL, CTIP1, EVI9, FLJ10173, KIAA1809
B-cell CLL/lymphoma 11A (zinc finger protein)
|
|
Application Data:
|
Western Blot analysis of BCL11A expression in transfected 293T cell line by BCL11A monoclonal antibody (M03), clone 3D9.
Lane 1: BCL11A transfected lysate(26.865 KDa).
Lane 2: Non-transfected lysate.
|
|
|
Background:
|
|
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]
|
|
Background References:
|
|
|
|
Product Citations:
|
|
|
|
Application Notes:
|
| ELISA | 1ug/ml~3ng/ml |
| Western blot | 1:500~1000 |
|
|
Format:
|
|
Clear, colorless solution in phosphate buffered saline, pH 7.2 .
|
|
Storage:
|
|
For continuous use, store at 2-8°C for one-two days. For extended storage, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
|
|
Precautions:
|
|
This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
|
