|
Catalog #
|
Source:
|
Lot #
|
Size:
|
|
AT1852a
|
mouse
|
|
0.1mg
|
|
Type:
|
Accession:
|
Clone Name:
|
Isotype:
|
|
Mab
|
AAH08876
|
2A6-2A4
|
IgG1 kappa
|
|
Applications:
|
Reactivity:
|
MW:
|
|
ELISA,S-ELISA,WB-Ce,WB-Re
|
H
|
25454 Da
|
|
Target/Specificity:
|
|
EDN3 (AAH08876, 1 a.a. ~ 239 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
|
|
Other Names:
|
|
ET3, MGC15067, MGC61498
endothelin 3
|
|
Application Data:
|
EDN3 monoclonal antibody (M01), clone 2A6-2A4 Western Blot analysis of EDN3 expression in LNCaP ( Cat # L004V1 ). |
Detection limit for recombinant GST tagged EDN3 is approximately 0.3ng/ml as a capture antibody. |
|
|
Background:
|
|
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq]
|
|
Background References:
|
|
|
|
Product Citations:
|
|
|
|
Application Notes:
|
| ELISA | 1ug/ml~3ng/ml |
| Western blot | 1:500~1000 |
|
|
Format:
|
|
Clear, colorless solution in phosphate buffered saline, pH 7.2 .
|
|
Storage:
|
|
For continuous use, store at 2-8°C for one-two days. For extended storage, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
|
|
Precautions:
|
|
This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
|
