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Catalog #
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Source:
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Lot #
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Size:
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AT4505a
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mouse
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0.1mg
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Type:
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Accession:
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Clone Name:
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Isotype:
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Mab
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AAH39174
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2C6-1B5
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IgG1 kappa
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Applications:
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Reactivity:
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MW:
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ELISA,IF,WB-Ce,WB-Re
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H
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123799 Da
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Target/Specificity:
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VCL (AAH39174, 1 a.a. ~ 1067 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Other Names:
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vinculin
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Application Data:
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Immunofluorescence of monoclonal antibody to VCL (AT4505a) on HeLa cell . [antibody concentration 10 ug/ml] |
VCL monoclonal antibody (M01), clone 2C6-1B5 Western Blot analysis of VCL expression in Hela ( Cat # L013V1 ). |
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Background:
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Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq]
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Background References:
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Product Citations:
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Application Notes:
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| ELISA | 1ug/ml~3ng/ml |
| Western blot | 1:500~1000 |
| Immunofluorescence | |
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Format:
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Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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Storage:
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For continuous use, store at 2-8°C for one-two days. For extended storage, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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