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Catalog #
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Source:
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Lot #
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Size:
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BP3508a
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In vitro synthesis
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SD080603M
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0.1 mg
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Concentration:
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Accession:
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Synthesis ID:
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Isotype:
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powder
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NP_036472
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110161
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Applications:
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Reactivity:
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MW (kDa):
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1749.4 Da
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Target/Specificity:
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The synthetic peptide sequence used to generate the antibody AP3508a was selected from the region of human Phospho-NFATC2-pS326. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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Other Names:
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NFAT1; NFATP; KIAA0611
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Application Data:
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Background:
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NFATC2 is a member of the nuclear factor of activated T cells (NFAT) family. This protein is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). It is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response.
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Background References:
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- Golks,A., EMBO J. 26 (20), 4368-4379 (2007)
- Dong,X., J. Biol. Chem. 282 (41), 30303-30310 (2007)
- Gibson,H.M., J. Immunol. 179 (6), 3831-3840 (2007)
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Product Citations:
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Application Notes:
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Format:
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Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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